Interferon Alpha-Inducible Protein 27 Expression Is Linked to Disease Severity in Chronic Infection of Both HIV-1 and HIV-2

Disease progression is slower in HIV-2, as compared with HIV-1 infection, accordance low or undetectable plasma viremia at viral setpoint. However, it unclear why most HIV-2 infected individuals are still risk of developing AIDS. To explore if specific host responses linked to HIV disease severity, we have blood gene expression profiles between seronegative and HIV-1, dually HIV-1/HIV-2 individuals. In this study the encoding Interferon alpha-inducible protein 27 (IFI27) was found be differentially expressed. Detailed analysis revealed significantly higher IFI27 individuals, irrespectively type. Moreover, than Multiple linear regression analysis, adjusting for age sex, showed also that load strongest predictor expression, followed by CD4% line this, viremic, aviremic Still, displayed elevated Furthermore, correlated markers previously inflammation infection. Taken together, our findings suggest sustained elevation type I interferon signaling, here reflected chronic infection phase, a key pathogenic feature both HIV-2.